Known primarily as a draughtsman and printmaker, Mundie's most recent artistic output has concentrated on pen and ink drawings and woodcuts. Mundie's drawings, paintings and prints have been exhibited widely at many locations, including: The Creative Artists Network, Federal Reserve Bank (Philadelphia), The Pennsylvania Academy of the Fine Arts, The University of Pennsylvania, Samuel S. Fleisher Art Memorial, Townhouse Gallery (Belfast, Northern Ireland), Biet-Gavriel (Israel), Hunterdon Museum of Art, Kyoto Municipal Museum Annex (Japan), The Pittsburgh Center for the Arts, Nommo Gallery (Kampala, Uganda), Boston University, David Young Gallery at Marie Curie House (Edinburgh, Scotland), and many others.

Drawings from the artist's popular and provocative series called Prodigies have been exhibited at Creative Artists Network, The Philadelphia Foundation, The Free Library of Philadelphia, Nexus: Foundation for Today's Art, and MF Gallery (New York), among others. The series has also been featured as part of the Delaware Art Museum's Biennial 2000: Art at the New Millennium, and was the subject of two solo shows: a Challenge Exhibition at the Samuel S. Fleisher Art Memorial, and the third exhibition in the Emerging Artist Series at the Woodmere Art Museum. In May 2005, several of these drawings were on view at the Redux Contemporary Art Center (Charleston SC) as part of the exhibition Alive Inside: The Lure and Lore of the Sideshow, curated by author Mark Sloan. The following year this show was remounted at Purdue University. In the fall of 2006, Mundie mounted the largest solo exhibition of these works to date at the Delaware Center for the Contemporary Arts, entitled Congress of Oddities: James G. Mundie's Prodigies.

Mundie has received numerous awards for his work, including a Creative Artists Network service grant, the Simone C. Titone Memorial Award from the Pennsylvania Academy of the Fine Arts, the Joseph Domjon Memorial Award from the Print Club of Albany, and others. In 2007, Mundie received the Alumni Travel Grant from the Center for Emerging Visual Artists, which he used to visit anatomical collections in several European museums. The photographs and drawings he produced there form the basis of a new body of work, Cabinet of Curiosities. Most recently, James G. Mundie received a 2008 fellowship from the Pennsylvania Council on the Arts.

Mundie's work appears in the collections of The Book Arts Press, The New York Public Library, The Print Club of Albany, The Spencer Museum of Art, The Kyoto International Woodprint Association, The University of Kentucky Art Museum, and others, including numerous private collections.

James Mundie resides in Philadelphia with his wife, fellow artist Kate Kern Mundie, and their sons Declan and Aidan.