Congential (harlequin) ichthyosis

Ink drawing of two extreme examples of harlequin ichthyosis from the anatomy collection of Musée Dupuytren in Paris. Infants born with this condition have skin that grows rapidly into armor-like plates of trapezoidal shapes separated by deep cracks. This thickened skin affects the shapes of facial features, limits mobility, and impedes growth and bodily temperature regulation. While life expectancy among those born with disease is improving, the world-wide mortality rate during infancy remains around 50%.